Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus

Tumor-targeting oncolytic viruses such as vaccinia virus (VV) are attractive cancer therapeutic agents that act through multiple mechanisms to provoke both tumor lysis and anti-tumor immune responses. However, delivery of these agents remains restricted to intra-tumoral administration, which prevent...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Ferguson, Mark S., Chard Dunmall, Louisa S., Gangeswaran, Rathi, Marelli, Giulia, Tysome, James R., Burns, Emily, Whitehead, Maria A., Aksoy, Ezra, Alusi, Ghassan, Hiley, Crispin, Ahmed, Jay, Vanhaesebroeck, Bart, Lemoine, Nicholas R., Wang, Yaohe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210704/
https://ncbi.nlm.nih.gov/pubmed/32145202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.02.017
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