Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood

Our early-life environment has a profound influence on developing organs that impacts metabolic function and determines disease susceptibility across the life-course. Using a rat model for exposure to an endocrine disrupting chemical (EDC), we show that early-life chemical exposure causes metabolic...

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Publicado en:Nat Commun
Main Authors: Treviño, Lindsey S., Dong, Jianrong, Kaushal, Ahkilesh, Katz, Tiffany A., Jangid, Rahul Kumar, Robertson, Matthew J., Grimm, Sandra L., Ambati, Chandra Shekar R., Putluri, Vasanta, Cox, Aaron R., Kim, Kang Ho, May, Thaddeus D., Gallo, Morgan R., Moore, David D., Hartig, Sean M., Foulds, Charles E., Putluri, Nagireddy, Coarfa, Cristian, Walker, Cheryl Lyn
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210260/
https://ncbi.nlm.nih.gov/pubmed/32385268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15847-z
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