Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood

Our early-life environment has a profound influence on developing organs that impacts metabolic function and determines disease susceptibility across the life-course. Using a rat model for exposure to an endocrine disrupting chemical (EDC), we show that early-life chemical exposure causes metabolic...

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Pubblicato in:Nat Commun
Autori principali: Treviño, Lindsey S., Dong, Jianrong, Kaushal, Ahkilesh, Katz, Tiffany A., Jangid, Rahul Kumar, Robertson, Matthew J., Grimm, Sandra L., Ambati, Chandra Shekar R., Putluri, Vasanta, Cox, Aaron R., Kim, Kang Ho, May, Thaddeus D., Gallo, Morgan R., Moore, David D., Hartig, Sean M., Foulds, Charles E., Putluri, Nagireddy, Coarfa, Cristian, Walker, Cheryl Lyn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210260/
https://ncbi.nlm.nih.gov/pubmed/32385268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15847-z
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