SUN-LB5 GnRHR ECL-2 Epitopes Targeted by Activating Autoantibodies in Polycystic Ovary Syndrome

Background: Activating autoantibodies (AAb) are directed to the gonadotropin releasing hormone receptor second extracellular loop (GnRHR-ECL2) and are pathogenic when induced in rats. We previously reported GnRHR-ECL2-AAb were elevated in sera from patients with PCOS (Rotterdam criteria) compared to...

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Détails bibliographiques
Publié dans:J Endocr Soc
Auteurs principaux: Guo, Yankai, Deng, Jielin, Gege, Zhang, Li, Hongliang, Weeden, Elizabeth A, Aston, Christopher E, Burks, Heather R, Craig, Tasha B, Yu, Xichun, Kem, David C
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Reproductive Endocrinology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208532/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2095
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