SUN-213 The Role of Filamin A (FLNA) in the Regulation of Insulin-Like Growth Factor System in Adrenocortical Carcinomas

Adrenocortical carcinomas (ACCs) are rare endocrine tumors with poor prognosis. They overexpress insulin-like growth factor 2 (IGF2), that drives a proliferative autocrine loop by binding to IGF1R and IR, with molecular dynamics still poorly identified. Although promising, IGF1R/IR-targeted therapie...

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Библиографические подробности
Опубликовано в: :J Endocr Soc
Главные авторы: Peverelli, Erika, Catalano, Rosa, Giardino, Elena, Treppiedi, Donatella, Mangili, Federica, Morelli, Valentina, Mannelli, Massimo, Spada, Anna, Arosio, Maura, Mantovani, Giovanna
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
Adrenal
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208431/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.501
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