OR05-05 Lethal ERα-Dependent Hyperactivation of the Unfolded Protein Response Induces Complete Regression Without Recurrence of Primary and Metastatic Breast Cancer

Metastatic estrogen receptor α (ERα) positive breast cancer is presently incurable and most patients die within 7 years. From a medicinal chemistry program, we identified a novel small molecule that acts through ERα to kill breast cancer cells and often induces complete regression without recurrence...

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Publicat a:J Endocr Soc
Autors principals: Duraki, Darjan, Boudreau, Matthew W, Wang, Lawrence, Mao, Chengjian, Tang, Bingtao, Ma, Liqian, Roy, Edward J, Fan, Timothy M, Park, Ben Ho, Nelson, Erik R, Hergenrother, Paul J, Shapiro, David J
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Tumor Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208387/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.653
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