OR05-05 Lethal ERα-Dependent Hyperactivation of the Unfolded Protein Response Induces Complete Regression Without Recurrence of Primary and Metastatic Breast Cancer

Metastatic estrogen receptor α (ERα) positive breast cancer is presently incurable and most patients die within 7 years. From a medicinal chemistry program, we identified a novel small molecule that acts through ERα to kill breast cancer cells and often induces complete regression without recurrence...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Duraki, Darjan, Boudreau, Matthew W, Wang, Lawrence, Mao, Chengjian, Tang, Bingtao, Ma, Liqian, Roy, Edward J, Fan, Timothy M, Park, Ben Ho, Nelson, Erik R, Hergenrother, Paul J, Shapiro, David J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Tumor Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208387/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.653
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados