SAT-114 Loss of DHEA-Targeting SULT2b1b Sulfotransferase Exacerbates Aggressive Traits of Prostate Cancer

The prostate-expressed sulfotransferase SULT2B1b (SULT2B) regulates intracrine androgen homeostasis by mediating 3β-sulfation of DHEA, thus reducing the precursor pool in the androgen biosynthesis pathway. We explored how loss of SULT2B might influence prostate cancer progression. Results show that...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Song, Chung Seog, Park, Sulgi, Jiang, Shoulei, Osmulski, Pawel, Marck, Brett T, Matsumoto, Alvin M, Morrissey, Colm, Gaczynska, Maria E, Mostaghel, Elahe A, Chatterjee, Bandana
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Tumor Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208293/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1448
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