Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1

The high-energy sulfate donor 3′-phosphoadenosine-5′-phosphosulfate (PAPS), generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human sulfation pathways. Sulfotransferase SULT2A1 uses PAPS for sulfation of the androgen precursor dehydroepiandrosterone (DHEA), thereby red...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mueller, Jonathan W., Idkowiak, Jan, Gesteira, Tarsis F., Vallet, Cecilia, Hardman, Rebecca, van den Boom, Johannes, Dhir, Vivek, Knauer, Shirley K., Rosta, Edina, Arlt, Wiebke
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016456/
https://ncbi.nlm.nih.gov/pubmed/29743239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002248
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