OR28-03 Drug Repurposing Identifies Inhibitors of the Proteostasis Network to Augment Radioiodine Uptake in Combinatorial Approaches Targeting Thyroid Cancer

New combinatorial drug strategies are urgently needed to improve radioiodine (RAI) uptake and efficiently ablate thyroid cancer cells, thereby reducing the risk of recurrent disease. Drug repurposing offers the promise of identifying already approved compounds capable of inducing sodium iodide sympo...

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Vydáno v:J Endocr Soc
Hlavní autoři: Read, Martin L, Brookes, Katie, Fletcher, Alice, Thornton, Caitlin E M, Alshahrani, Mohammed, Khan, Rashida, Nieto, Hannah R, Adcock, Holly V, Webster, Jamie R M, Cox, Liam, Alderwick, Luke J, Boelaert, Kristien, Smith, Vicki E, McCabe, Christopher J
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Thyroid
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208217/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2135
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