Synaptic dysfunction induced by glycine‐alanine dipeptides in C9orf72‐ALS/FTD is rescued by SV2 replenishment

The most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an intronic hexanucleotide repeat expansion in the C9orf72 gene. In disease, RNA transcripts containing this expanded region undergo repeat‐associated non‐AUG translation to produce dipeptide repeat pro...

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Bibliografiske detaljer
Udgivet i:EMBO Mol Med
Main Authors: Jensen, Brigid K, Schuldi, Martin H, McAvoy, Kevin, Russell, Katelyn A, Boehringer, Ashley, Curran, Bridget M, Krishnamurthy, Karthik, Wen, Xinmei, Westergard, Thomas, Ma, Le, Haeusler, Aaron R, Edbauer, Dieter, Pasinelli, Piera, Trotti, Davide
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7207170/
https://ncbi.nlm.nih.gov/pubmed/32347002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910722
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