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miCLIP-MaPseq, a Substrate Identification Approach for Radical SAM RNA Methylating Enzymes
Although present across bacteria, the large family of radical SAM RNA methylating enzymes is largely uncharacterized. Escherichia coli RlmN, the founding member of the family, methylates an adenosine in 23S rRNA and several tRNAs to yield 2-methyladenosine (m(2)A). However, varied RNA substrate spec...
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| Izdano u: | J Am Chem Soc |
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| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7207077/ https://ncbi.nlm.nih.gov/pubmed/29782154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b02618 |
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