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Substrate-Assisted Hydroxylation and O-Demethylation in the Peroxidase-like Cytochrome P450 Enzyme CYP121
CYP121 is a P450 enzyme from Mycobacterium tuberculosis that catalyzes a C–C coupling reaction between the two aromatic rings on its native substrate cyclo(l-Tyr-l-Tyr) (cYY) to form mycocyclosin, a necessary product for cell survival. Unlike the typical P450 enzymes for hydroxylation, CYP121 is bel...
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| Gepubliceerd in: | ACS Catal |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7207044/ https://ncbi.nlm.nih.gov/pubmed/32391185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b04596 |
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