Substrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURES

Cytochrome P450 CYP121 is essential for the viability of Mycobacterium tuberculosis. Studies in vitro show that it can use the cyclodipeptide cyclo(l-Tyr-l-Tyr) (cYY) as a substrate. We report an investigation of the substrate and reaction specificities of CYP121 involving analysis of the interactio...

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Detalhes bibliográficos
Main Authors: Fonvielle, Matthieu, Le Du, Marie-Hélène, Lequin, Olivier, Lecoq, Alain, Jacquet, Mickaël, Thai, Robert, Dubois, Steven, Grach, Guillaume, Gondry, Muriel, Belin, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682536/
https://ncbi.nlm.nih.gov/pubmed/23620594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.443853
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