Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis

The gene encoding the cytochrome P450 CYP121 is essential for Mycobacterium tuberculosis. However, the CYP121 catalytic activity remains unknown. Here, we show that the cyclodipeptide cyclo(l-Tyr-l-Tyr) (cYY) binds to CYP121, and is efficiently converted into a single major product in a CYP121 activ...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Belin, Pascal, Le Du, Marie Hélène, Fielding, Alistair, Lequin, Olivier, Jacquet, Mickaël, Charbonnier, Jean-Baptiste, Lecoq, Alain, Thai, Robert, Courçon, Marie, Masson, Cédric, Dugave, Christophe, Genet, Roger, Pernodet, Jean-Luc, Gondry, Muriel
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2009
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678619/
https://ncbi.nlm.nih.gov/pubmed/19416919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812191106
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