Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis

The gene encoding the cytochrome P450 CYP121 is essential for Mycobacterium tuberculosis. However, the CYP121 catalytic activity remains unknown. Here, we show that the cyclodipeptide cyclo(l-Tyr-l-Tyr) (cYY) binds to CYP121, and is efficiently converted into a single major product in a CYP121 activ...

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Detalhes bibliográficos
Main Authors: Belin, Pascal, Le Du, Marie Hélène, Fielding, Alistair, Lequin, Olivier, Jacquet, Mickaël, Charbonnier, Jean-Baptiste, Lecoq, Alain, Thai, Robert, Courçon, Marie, Masson, Cédric, Dugave, Christophe, Genet, Roger, Pernodet, Jean-Luc, Gondry, Muriel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678619/
https://ncbi.nlm.nih.gov/pubmed/19416919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812191106
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