PDE3 Inhibition Reduces Epithelial Mast Cell Numbers in Allergic Airway Inflammation and Attenuates Degranulation of Basophils and Mast Cells

Epithelial mast cells are generally present in the airways of patients with allergic asthma that are inadequately controlled. Airway mast cells (MCs) are critically involved in allergic airway inflammation and contribute directly to the main symptoms of allergic patients. Phosphodiesterase 3 (PDE3)...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Beute, Jan, Ganesh, Keerthana, Nastiti, Hedwika, Hoogenboom, Robin, Bos, Vivica, Folkerts, Jelle, Schreurs, Marco W. J., Hockman, Steve, Hendriks, Rudi W., KleinJan, Alex
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206980/
https://ncbi.nlm.nih.gov/pubmed/32425769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00470
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