PDE3 Inhibition Reduces Epithelial Mast Cell Numbers in Allergic Airway Inflammation and Attenuates Degranulation of Basophils and Mast Cells

Epithelial mast cells are generally present in the airways of patients with allergic asthma that are inadequately controlled. Airway mast cells (MCs) are critically involved in allergic airway inflammation and contribute directly to the main symptoms of allergic patients. Phosphodiesterase 3 (PDE3)...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: Beute, Jan, Ganesh, Keerthana, Nastiti, Hedwika, Hoogenboom, Robin, Bos, Vivica, Folkerts, Jelle, Schreurs, Marco W. J., Hockman, Steve, Hendriks, Rudi W., KleinJan, Alex
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206980/
https://ncbi.nlm.nih.gov/pubmed/32425769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00470
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