Annotations capturing cell type-specific TF binding explain a large fraction of disease heritability

Regulatory variation plays a major role in complex disease and that cell type-specific binding of transcription factors (TF) is critical to gene regulation. However, assessing the contribution of genetic variation in TF-binding sites to disease heritability is challenging, as binding is often cell t...

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Détails bibliographiques
Publié dans:Hum Mol Genet
Auteurs principaux: van de Geijn, Bryce, Finucane, Hilary, Gazal, Steven, Hormozdiari, Farhad, Amariuta, Tiffany, Liu, Xuanyao, Gusev, Alexander, Loh, Po-Ru, Reshef, Yakir, Kichaev, Gleb, Raychauduri, Soumya, Price, Alkes L
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
General Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206853/
https://ncbi.nlm.nih.gov/pubmed/31595288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz226
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