SMN-deficiency disrupts SERCA2 expression and intracellular Ca(2+) signaling in cardiomyocytes from SMA mice and patient-derived iPSCs

Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by loss of alpha motor neurons and skeletal muscle atrophy. The disease is caused by mutations of the SMN1 gene that result in reduced functional expression of survival motor neuron (SMN) protein. SMN is ubiquitously expresse...

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Publicado en:Skelet Muscle
Main Authors: Khayrullina, Guzal, Moritz, Kasey E., Schooley, James F., Fatima, Naheed, Viollet, Coralie, McCormack, Nikki M., Smyth, Jeremy T., Doughty, Martin L., Dalgard, Clifton L., Flagg, Thomas P., Burnett, Barrington G.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206821/
https://ncbi.nlm.nih.gov/pubmed/32384912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-020-00232-7
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