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The role of the immunoproteasome in interferon-γ-mediated microglial activation

Microglia regulate the brain microenvironment by sensing damage and neutralizing potentially harmful insults. Disruption of central nervous system (CNS) homeostasis results in transition of microglia to a reactive state characterized by morphological changes and production of cytokines to prevent fu...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Moritz, Kasey E., McCormack, Nikki M., Abera, Mahlet B., Viollet, Coralie, Yauger, Young J., Sukumar, Gauthaman, Dalgard, Clifton L., Burnett, Barrington G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571106/
https://ncbi.nlm.nih.gov/pubmed/28839214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09715-y
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