SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC

Solute carrier family 27 member 5 (SLC27A5/FATP5) is involved in fatty acid transport and bile acid metabolism; however, little is known about its role in human diseases. Here, we first show that SLC27A5 expression is downregulated in hepatocellular carcinoma (HCC) by DNA hypermethylation, and reduc...

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Vydáno v:Cell Death Differ
Hlavní autoři: Gao, Qingzhu, Zhang, Guiji, Zheng, Yaqiu, Yang, Yi, Chen, Chang, Xia, Jie, Liang, Li, Lei, Chong, Hu, Yuan, Cai, Xuefei, Zhang, Wenlu, Tang, Hua, Chen, Yaxi, Huang, Ailong, Wang, Kai, Tang, Ni
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206086/
https://ncbi.nlm.nih.gov/pubmed/31367013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0399-1
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