Cytoprotective Nrf2 Pathway Is Induced In Chronically Txnrd 1-Deficient Hepatocytes

BACKGROUND: Metabolically active cells require robust mechanisms to combat oxidative stress. The cytoplasmic thioredoxin reductase/thioredoxin (Txnrd1/Txn1) system maintains reduced protein dithiols and provides electrons to some cellular reductases, including peroxiredoxins. PRINCIPAL FINDINGS: Her...

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Detalhes bibliográficos
Main Authors: Suvorova, Elena S., Lucas, Olivier, Weisend, Carla M., Rollins, MaryClare F., Merrill, Gary F., Capecchi, Mario R., Schmidt, Edward E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703566/
https://ncbi.nlm.nih.gov/pubmed/19584930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006158
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