Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration

Cells require ribonucleotide reductase (RNR) activity for DNA replication. In bacteria, electrons can flow from NADPH to RNR by either a thioredoxin-reductase- or a glutathione-reductase-dependent route. Yeast and plants artificially lacking thioredoxin reductases exhibit a slow-growth phenotype, su...

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Detalhes bibliográficos
Main Authors: Rollins, MaryClare F., van der Heide, Dana M., Weisend, Carla M., Kundert, Jean A., Comstock, Kristin M., Suvorova, Elena S., Capecchi, Mario R., Merrill, Gary F., Schmidt, Edward E.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894656/
https://ncbi.nlm.nih.gov/pubmed/20571049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.068106
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