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SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity
Lipophagy is a lysosomal lipolytic pathway that complements the actions of cytosolic neutral lipases. Chaperon-mediated autophagy (CMA) triggers lipid droplets (LDs) breakdown, to initiate lipolysis via either cytosolic lipases or macroautophagy. SIRT3, a mitochondrial NAD(+)-dependent deacetylase,...
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| Publicat a: | Cell Death Differ |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7206074/ https://ncbi.nlm.nih.gov/pubmed/31160717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0356-z |
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