Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis

Breast cancer stem cells (BCSCs) are tumor initiating cells that can self-renew and are highly tumorigenic and chemoresistant. Therefore, the identification of factors critical for BCSC function is vital for the development of therapies. Here, we report that DNMT1-mediated FOXO3a promoter hypermethy...

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Bibliografske podrobnosti
izdano v:Cell Death Differ
Main Authors: Liu, Hao, Song, Ying, Qiu, Huishi, Liu, Yanzhen, Luo, Kai, Yi, Yanmei, Jiang, Guanmin, Lu, Minying, Zhang, Zhijie, Yin, Jiang, Zeng, Shanshan, Chen, Xiangzhou, Deng, Min, Jia, Xiaoting, Gu, Yixue, Chen, Danyang, Zheng, Guopei, He, Zhimin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206060/
https://ncbi.nlm.nih.gov/pubmed/31296961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0389-3
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