SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation

Both the stress-response protein, SIRT1, and the cell cycle checkpoint kinase, CHK2, play critical roles in aging and cancer via the modulation of cellular homeostasis and the maintenance of genomic integrity. However, the underlying mechanism linking the two pathways remains elusive. Here, we show...

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Publicado no:Cell Death Differ
Main Authors: Zhang, Wenyu, Feng, Yanling, Guo, Qiqiang, Guo, Wendong, Xu, Hongde, Li, Xiaoman, Yi, Fei, Guan, Yi, Geng, Nanxi, Wang, Pingyuan, Cao, Longyue, O’Rourke, Brian P., Jo, Juhyeon, Kwon, Jiyun, Wang, Ruihong, Song, Xiaoyu, Lee, In Hye, Cao, Liu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206007/
https://ncbi.nlm.nih.gov/pubmed/31209362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0369-7
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