SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation

Both the stress-response protein, SIRT1, and the cell cycle checkpoint kinase, CHK2, play critical roles in aging and cancer via the modulation of cellular homeostasis and the maintenance of genomic integrity. However, the underlying mechanism linking the two pathways remains elusive. Here, we show...

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Publicat a:Cell Death Differ
Autors principals: Zhang, Wenyu, Feng, Yanling, Guo, Qiqiang, Guo, Wendong, Xu, Hongde, Li, Xiaoman, Yi, Fei, Guan, Yi, Geng, Nanxi, Wang, Pingyuan, Cao, Longyue, O’Rourke, Brian P., Jo, Juhyeon, Kwon, Jiyun, Wang, Ruihong, Song, Xiaoyu, Lee, In Hye, Cao, Liu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206007/
https://ncbi.nlm.nih.gov/pubmed/31209362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0369-7
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