SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation

Both the stress-response protein, SIRT1, and the cell cycle checkpoint kinase, CHK2, play critical roles in aging and cancer via the modulation of cellular homeostasis and the maintenance of genomic integrity. However, the underlying mechanism linking the two pathways remains elusive. Here, we show...

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Bibliografske podrobnosti
izdano v:Cell Death Differ
Main Authors: Zhang, Wenyu, Feng, Yanling, Guo, Qiqiang, Guo, Wendong, Xu, Hongde, Li, Xiaoman, Yi, Fei, Guan, Yi, Geng, Nanxi, Wang, Pingyuan, Cao, Longyue, O’Rourke, Brian P., Jo, Juhyeon, Kwon, Jiyun, Wang, Ruihong, Song, Xiaoyu, Lee, In Hye, Cao, Liu
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206007/
https://ncbi.nlm.nih.gov/pubmed/31209362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0369-7
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