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Characterizing Single-Molecule Conformational Changes Under Shear Flow with Fluorescence Microscopy

Single-molecule behavior under mechanical perturbation has been characterized widely to understand many biological processes. However, methods such as atomic force microscopy have limited temporal resolution, while Förster resonance energy transfer (FRET) only allow conformations to be inferred. Flu...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: Pisapati, Avani V., Wang, Yi, Blauch, Megan E., Wittenberg, Nathan J., Cheng, Xuanhong, Zhang, X. Frank
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205595/
https://ncbi.nlm.nih.gov/pubmed/32065139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/60784
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