Probing Conformational Changes of Gramicidin Ion Channels by Single-Molecule Patch-Clamp Fluorescence Microscopy

Complex conformational changes influence and regulate the dynamics of ion channels. Such conformational changes are stochastic and often inhomogeneous, which makes it extremely difficult, if not impossible, to characterize them by ensemble-averaged experiments or by single-channel recordings of the...

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Main Authors: Harms, Greg S., Orr, Galya, Montal, Mauricio, Thrall, Brian D., Colson, Steve D., Lu, H. Peter
Format: Artigo
Sprog:Inglês
Udgivet: Biophysical Society 2003
Fag:
Photobiophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303355/
https://ncbi.nlm.nih.gov/pubmed/12944296
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