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Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex

We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis. The topology of ubonodin is unprecedented amongst lasso peptides with 18 of its 28 amino acids found in the mechanically-bonded loop segment. Ub...

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Vydáno v:Chembiochem
Hlavní autoři: Cheung-Lee, Wai Ling, Parry, Madison E., Zong, Chuhan, Cartagena, Alexis Jaramillo, Darst, Seth A., Connell, Nancy D., Russo, Riccardo, Link, A. James
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205569/
https://ncbi.nlm.nih.gov/pubmed/31765515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900707
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