Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release

Glucokinase (GK) is highly expressed in the hypothalamic paraventricular nucleus (PVN); however, its role is currently unknown. We found that GK in the PVN acts as part of a glucose-sensing mechanism within the PVN that regulates glucose homeostasis by controlling glucagon-like peptide 1 (GLP-1) rel...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Ma, Yue, Ratnasabapathy, Risheka, De Backer, Ivan, Izzi-Engbeaya, Chioma, Nguyen-Tu, Marie-Sophie, Cuenco, Joyceline, Jones, Ben, John, Christopher D., Lam, Brian Y.H., Rutter, Guy A., Yeo, Giles S.H., Dhillo, Waljit S., Gardiner, James
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205434/
https://ncbi.nlm.nih.gov/pubmed/32229720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132760
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