Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis

AIMS: To investigate the role of arcuate glucokinase (GK) in the regulation of glucose homeostasis. MATERIALS AND METHODS: A recombinant adeno‐associated virus expressing either GK or an antisense GK construct was used to alter GK activity specifically in the hypothalamic arcuate nucleus (arc). GK a...

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Vydáno v:Diabetes Obes Metab
Hlavní autoři: Ma, Yue, Ratnasabapathy, Risheka, Izzi‐Engbeaya, Chioma, Nguyen‐Tu, Marie‐Sophie, Richardson, Errol, Hussain, Sufyan, De Backer, Ivan, Holton, Christopher, Norton, Mariana, Carrat, Gaelle, Schwappach, Blanche, Rutter, Guy A., Dhillo, Waljit S., Gardiner, James
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2018
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099255/
https://ncbi.nlm.nih.gov/pubmed/29748994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dom.13359
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