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Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

Many proteins contain multiple folded domains separated by flexible linkers, and the ability to describe the structure and conformational heterogeneity of such flexible systems pushes the limits of structural biology. Using the three-domain protein TIA-1 as an example, we here combine coarse-grained...

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Dettagli Bibliografici
Pubblicato in:PLoS Comput Biol
Autori principali: Larsen, Andreas Haahr, Wang, Yong, Bottaro, Sandro, Grudinin, Sergei, Arleth, Lise, Lindorff-Larsen, Kresten
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205321/
https://ncbi.nlm.nih.gov/pubmed/32339173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007870
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