Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

Many proteins contain multiple folded domains separated by flexible linkers, and the ability to describe the structure and conformational heterogeneity of such flexible systems pushes the limits of structural biology. Using the three-domain protein TIA-1 as an example, we here combine coarse-grained...

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Publicat a:PLoS Comput Biol
Autors principals: Larsen, Andreas Haahr, Wang, Yong, Bottaro, Sandro, Grudinin, Sergei, Arleth, Lise, Lindorff-Larsen, Kresten
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205321/
https://ncbi.nlm.nih.gov/pubmed/32339173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007870
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