Catalytically active Cas9 mediates transcriptional interference to facilitate bacterial virulence

In addition to defense against foreign DNA, the CRISPR-Cas9 system of Francisella novicida represses expression of an endogenous immunostimulatory lipoprotein. We investigated the specificity and molecular mechanism of this regulation, demonstrating that Cas9 has a highly specific regulon of four ge...

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Pubblicato in:Mol Cell
Autori principali: Ratner, Hannah K., Escalera-Maurer, Andrés, Rhun, Anaïs Le, Jaggavarapu, Siddharth, Wozniak, Jessie E., Crispell, Emily K., Charpentier, Emmanuelle, Weiss, David S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205310/
https://ncbi.nlm.nih.gov/pubmed/31256988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.05.029
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