AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes

Somatic hypermutation (SHM) of the immunoglobulin variable (IgV) loci is a key process in antibody affinity maturation. The enzyme activation-induced deaminase (AID), initiates SHM by creating C → U mismatches on single-stranded DNA (ssDNA). AID has preferential hotspot motif targets in the context...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Tang, Catherine, Bagnara, Davide, Chiorazzi, Nicholas, Scharff, Matthew D., MacCarthy, Thomas
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204545/
https://ncbi.nlm.nih.gov/pubmed/32425948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00788
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