Overlapping hotspots in CDRs are critical sites for V region diversification

Activation-induced deaminase (AID) mediates the somatic hypermutation (SHM) of Ig variable (V) regions that is required for the affinity maturation of the antibody response. An intensive analysis of a published database of somatic hypermutations that arose in the IGHV3-23*01 human V region expressed...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wei, Lirong, Chahwan, Richard, Wang, Shanzhi, Wang, Xiaohua, Pham, Phuong T., Goodman, Myron F., Bergman, Aviv, Scharff, Matthew D., MacCarthy, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343087/
https://ncbi.nlm.nih.gov/pubmed/25646473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500788112
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