The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis

BACKGROUND: In the past 15 years, numerous studies have described aberrant DNA methylation of imprinted genes (e.g. MEST and H19) in sperm of oligozoospermic men, but the prevalence and genomic extent of abnormal methylation patterns have remained unknown. RESULTS: Using deep bisulfite sequencing (D...

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Bibliographic Details
Published in:Clin Epigenetics
Main Authors: Leitão, Elsa, Di Persio, Sara, Laurentino, Sandra, Wöste, Marius, Dugas, Martin, Kliesch, Sabine, Neuhaus, Nina, Horsthemke, Bernhard
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204326/
https://ncbi.nlm.nih.gov/pubmed/32375885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00854-0
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