The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis

BACKGROUND: In the past 15 years, numerous studies have described aberrant DNA methylation of imprinted genes (e.g. MEST and H19) in sperm of oligozoospermic men, but the prevalence and genomic extent of abnormal methylation patterns have remained unknown. RESULTS: Using deep bisulfite sequencing (D...

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Vydáno v:Clin Epigenetics
Hlavní autoři: Leitão, Elsa, Di Persio, Sara, Laurentino, Sandra, Wöste, Marius, Dugas, Martin, Kliesch, Sabine, Neuhaus, Nina, Horsthemke, Bernhard
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204326/
https://ncbi.nlm.nih.gov/pubmed/32375885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00854-0
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