The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis

BACKGROUND: In the past 15 years, numerous studies have described aberrant DNA methylation of imprinted genes (e.g. MEST and H19) in sperm of oligozoospermic men, but the prevalence and genomic extent of abnormal methylation patterns have remained unknown. RESULTS: Using deep bisulfite sequencing (D...

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Bibliografiska uppgifter
I publikationen:Clin Epigenetics
Huvudupphovsmän: Leitão, Elsa, Di Persio, Sara, Laurentino, Sandra, Wöste, Marius, Dugas, Martin, Kliesch, Sabine, Neuhaus, Nina, Horsthemke, Bernhard
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2020
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Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204326/
https://ncbi.nlm.nih.gov/pubmed/32375885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00854-0
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