The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis

BACKGROUND: In the past 15 years, numerous studies have described aberrant DNA methylation of imprinted genes (e.g. MEST and H19) in sperm of oligozoospermic men, but the prevalence and genomic extent of abnormal methylation patterns have remained unknown. RESULTS: Using deep bisulfite sequencing (D...

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Bibliografiske detaljer
Udgivet i:Clin Epigenetics
Main Authors: Leitão, Elsa, Di Persio, Sara, Laurentino, Sandra, Wöste, Marius, Dugas, Martin, Kliesch, Sabine, Neuhaus, Nina, Horsthemke, Bernhard
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204326/
https://ncbi.nlm.nih.gov/pubmed/32375885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00854-0
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