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A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis
H2AX safeguards genomic stability in a dose-dependent manner; however, mechanisms governing its proteostasis are poorly understood. Here, we identify a PRMT5-RNF168-SMURF2 cascade that regulates H2AX proteostasis. We show that PRMT5 sustains the expression of RNF168, an E3 ubiquitin ligase essential...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7204040/ https://ncbi.nlm.nih.gov/pubmed/31533041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.031 |
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