Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells

There are eight human Src-family tyrosine kinases (SFKs). SFK members c-Src, c-Yes, Fyn, and Lyn are expressed in various cancer cells. SFK kinase activity is negatively regulated by Csk tyrosine kinase. Reduced activity of Csk causes aberrant activation of SFKs, which can be degraded by a compensat...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Kuga, Takahisa, Yamane, Yuka, Hayashi, Soujirou, Taniguchi, Masanari, Yamaguchi, Naoto, Yamagishi, Nobuyuki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203244/
https://ncbi.nlm.nih.gov/pubmed/32376886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64624-x
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