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Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells

There are eight human Src-family tyrosine kinases (SFKs). SFK members c-Src, c-Yes, Fyn, and Lyn are expressed in various cancer cells. SFK kinase activity is negatively regulated by Csk tyrosine kinase. Reduced activity of Csk causes aberrant activation of SFKs, which can be degraded by a compensat...

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Foilsithe in:Sci Rep
Main Authors: Kuga, Takahisa, Yamane, Yuka, Hayashi, Soujirou, Taniguchi, Masanari, Yamaguchi, Naoto, Yamagishi, Nobuyuki
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203244/
https://ncbi.nlm.nih.gov/pubmed/32376886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64624-x
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