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Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis

Mitochondria physically associate with the endoplasmic reticulum to coordinate interorganelle calcium transfer and regulate fundamental cellular processes, including inflammation. Deregulated endoplasmic reticulum–mitochondria cross-talk can occur in cystic fibrosis, contributing to hyperinflammatio...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Rimessi, Alessandro, Pozzato, Chiara, Carparelli, Lorenzo, Rossi, Alice, Ranucci, Serena, De Fino, Ida, Cigana, Cristina, Talarico, Anna, Wieckowski, Mariusz R., Ribeiro, Carla M. P., Trapella, Claudio, Rossi, Giacomo, Cabrini, Giulio, Bragonzi, Alessandra, Pinton, Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202873/
https://ncbi.nlm.nih.gov/pubmed/32494695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax9093
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