Autophagy prevents hippocampal α-synuclein oligomerization and early cognitive dysfunction after anesthesia/surgery in aged rats

Stress-induced α-synuclein aggregation, especially the most toxic species (oligomers), may precede synaptic and cognitive dysfunction. Under pathological conditions, α-synuclein is degraded primarily through the autophagic/lysosomal pathway. We assessed the involvement of autophagy in α-synuclein ag...

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Dettagli Bibliografici
Pubblicato in:Aging (Albany NY)
Autori principali: Yang, Ning, Li, Zhengqian, Han, Dengyang, Mi, Xinning, Tian, Miao, Liu, Taotao, Li, Yue, He, Jindan, Kuang, Chongshen, Cao, Yiyun, Li, Lunxu, Ni, Cheng, Wang, John Q., Guo, Xiangyang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202547/
https://ncbi.nlm.nih.gov/pubmed/32335546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103074
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