Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21(WAF1)-PKCζ pathway in p16(INK4a)-silenced cells

Mitochondrial dysfunction is linked to age-related senescence phenotypes. We report here the pathway increasing nucleoid remodeling and biogenesis in mitochondria during the senescence of foreskin human diploid fibroblasts (fs-HDF) and WI-38 cells. Replicative senescence in fs-HDF cells increased mi...

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Dades bibliogràfiques
Publicat a:Aging (Albany NY)
Autors principals: Lee, Yun Yeong, Choi, Yeon Seung, Kim, Do Wan, Cheong, Jae Youn, Song, Kye Yong, Ryu, Min Sook, Lim, In Kyoung
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202532/
https://ncbi.nlm.nih.gov/pubmed/32330121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103029
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