Regulations of Reversal of Senescence by PKC Isozymes in Response to 12-O-Tetradecanoylphorbol-13-Acetate via Nuclear Translocation of pErk1/2

The mechanism by which 12-O-tetradecanoylphorbol-13-acetate (TPA) bypasses cellular senescence was investigated using human diploid fibroblast (HDF) cell replicative senescence as a model. Upon TPA treatment, protein kinase C (PKC) α and PKCβ1 exerted differential effects on the nuclear translocatio...

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Bibliographic Details
Published in:Mol Cells
Main Authors: Lee, Yun Yeong, Ryu, Min Sook, Kim, Hong Seok, Suganuma, Masami, Song, Kye Yong, Lim, In Kyoung
Format: Artigo
Language:Inglês
Published: Korean Society for Molecular and Cellular Biology 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794609/
https://ncbi.nlm.nih.gov/pubmed/26912086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2016.2362
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