Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21

Psoriasis is a chronic Th1/Th17 lymphocytes-mediated inflammatory skin disease, in which epidermal keratinocytes exhibit a peculiar senescent state, resistance to apoptosis and the acquisition of senescence-associated secretory phenotype (SASP). SASP consists of the release of soluble factors, inclu...

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Bibliographische Detailangaben
Veröffentlicht in:Aging (Albany NY)
Hauptverfasser: Mercurio, Laura, Lulli, Daniela, Mascia, Francesca, Dellambra, Elena, Scarponi, Claudia, Morelli, Martina, Valente, Carola, Carbone, Maria Luigia, Pallotta, Sabatino, Girolomoni, Giampiero, Albanesi, Cristina, Pastore, Saveria, Madonna, Stefania
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202509/
https://ncbi.nlm.nih.gov/pubmed/32302288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103045
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