Selective Immunomodulation of Inflammatory Pathways in Keratinocytes by the Janus Kinase (JAK) Inhibitor Tofacitinib: Implications for the Employment of JAK-Targeting Drugs in Psoriasis

IFN-γ and IL-22 are deeply involved in the pathogenesis of psoriasis, as they boost the expression of inflammatory genes and alter proliferative and differentiative programs in keratinocytes. The JAK1/JAK2/STAT1 and JAK1/TYK2/STAT3 pathways triggered by IFN-γ and IL-22, respectively, are aberrantly...

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Detalhes bibliográficos
Publicado no:J Immunol Res
Main Authors: Morelli, Martina, Scarponi, Claudia, Mercurio, Laura, Facchiano, Francesco, Pallotta, Sabatino, Madonna, Stefania, Girolomoni, Giampiero, Albanesi, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276416/
https://ncbi.nlm.nih.gov/pubmed/30581877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/7897263
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